Alex Marquez ended Friday Practice at Barcelona fastest with a 1:39.950, heading a session disrupted by crashes for Jorge Martin, Pedro Acosta and Brad Binder. Martin lost the front at Turn 12 at the midway stage and hit an air fence, walking away giving a thumbs up before returning to the Aprilia garage in time for practice starts. Jack Miller was the top Yamaha in eighth and Johann Zarco led Honda in tenth.

